Single multimode fibre for in vivo light-field-encoded endoscopic imaging

Super-resolution microscopy normally requiring complex and cumbersome optics is not applicable for in situ imaging through a narrow channel. Here, we demonstrate single hair-thin multimode fiber (MMF) endoscope (less than 250 ${\mu}m$) vivo light-field nano-imaging, which called spatial-frequency tracking adaptive beacon encoded nano-endoscopy (STABLE nano-endoscopy) that enables three-dimensional (3D) subcellular-scale imaging. Spatial-frequency provides up to $10^3$ Hz disorder ensures stable long-haul MMFs (up 200 m) under various conditions. Full-vector modulation fluorescence emission difference are combined enhance the signal-to-noise ratio two times improve resolution sub-diffraction-limited nm (${\lambda}/3NA$). STABLE white-light endoscopy (WLE) integrated achieve cross-scale inside lumen. This high-resolution robust observation minimally invasive manner paves way gain deeper understanding of disease mechanisms bridge clinical biological sciences.